In the summary thrombotic thrombocytopenic purpura ttp. Purpura is a disease in which there is leakage of blood out of the blood vessels in the skin or mucosa, causing the presence of painless purplish spots, called petechiae small and large number stains or ecchymoses larger patches. Protocolo clinico e diretrizes terapeuticas purpura. Purpura results from the extravasation of blood cells into the skin andor mucous membranes giving rise to small purple coloured areas that do not disappear under pressure. Trombocitopenia inmune primaria tip del adulto en mexico. It is more common in women in the third and fourth decades, posible even in postpartum. The clots can limit or block the flow of oxygenrich blood to the. Thrombotic thrombocytopenic purpura national heart, lung. Purpura trombocitopenica trombotica sintomas, tratamento. Protocolo clinico e diretrizes terapeuticas portaria sasms n. Pdf trombocitopenia inmunitaria primaria researchgate. Immune thrombocytopenia itp is an acquired form of thrombocytopenia that is primarily due to autoantibodymediated destruction of platelets. Thrombotic thrombocytopenic purpura blood american. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext.
The last 20 years have been marked by the connection between an old disease, the thrombotic thrombocytopenic purpura ttp, 1 and a young protein, adamts a disintegrin and. Immune thrombocytopenia purpura itp, also known as idiopathic thrombocytopenic purpura, is a type of thrombocytopenic purpura defined as an isolated low platelet count with a normal bone marrow in. Treatment of thrombotic thrombocytopenic purpura using therapeutic apheresis in a patient with systemic lupus erythematosus. Thrombocytopenic purpura is mostly responsible for episodes of mucocutaneous bleeding. Gutarra galvn medico pediatra hospital nacional ramiro priale p. In the literature, there are 12 reports of an association between celiac disease e immune thrombocytopenic purpura. Thrombotic thrombocytopenic purpura ttp is an acute, rare, potentially lifethreatening disorder, presenting with thrombocytopenia, hemolytic anemia, and clinical consequences of. Thrombotic thrombocytopenic purpura ttp is a rare blood disorder. The etiopathogenic mechanisms may result from abnormalities in any of the three components of hemostasis. In ttp, blood clots form in small blood vessels throughout the body.